BDBM50617732 CHEMBL5403510::US20250353857, Compound JH06-118

SMILES C[C@@H](Nc1ncnc2[nH]c(cc12)-c1ccc(CO)cc1)c1ccccc1

InChI Key InChIKey=JFFNMSINEFWPKX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50617732   

TargetEpidermal growth factor receptor(Human)
Norwegian University of Science and Technology (NTNU)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50617732BDBM50617732(CHEMBL5403510 | US20250353857, Compound JH06-118)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50617732BDBM50617732(CHEMBL5403510 | US20250353857, Compound JH06-118)
Affinity DataIC50: 12nMAssay Description:The compounds were supplied in a 10 mM DMSO solution, and enzymatic CSF1R inhibition potency was determined by Invitrogen (TermoFisher) using their Z...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 50617732BDBM50617732(CHEMBL5403510 | US20250353857, Compound JH06-118)
Affinity DataIC50: 12nMAssay Description:Inhibition of CSF1R (530 to 910 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50617732BDBM50617732(CHEMBL5403510 | US20250353857, Compound JH06-118)
Affinity DataIC50: 12nMAssay Description:Inhibition of CSF1R (unknown origin) using FRET-peptide as substrate incubated in presence of ATP by FRET based Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed