BDBM50618105 CHEMBL5426481

SMILES Clc1ccc(nc1)N1CCN(CCCCc2nc3ccccc3s2)CC1

InChI Key InChIKey=HKDOASHONDCKDU-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50618105   

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  4.85nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  104nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  104nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataIC50: 414nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  830nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataKi:  830nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataIC50: 1.08E+4nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618105(CHEMBL5426481 | US12122771, Compound 3)
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed