BDBM50618114 CHEMBL5434856

SMILES COc1ccc(nc1)C1CCN(CCCc2nc3ccccc3s2)CC1

InChI Key InChIKey=NNGCPQMNTNEUCA-UHFFFAOYSA-N

Data  6 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50618114   

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  22nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataIC50: 173nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataIC50: 333nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataIC50: 2.34E+3nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  4.86E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  4.86E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

US Patent
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataIC50: 8.46E+3nMAssay Description:Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataIC50: 1.43E+4nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  1.74E+4nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618114(CHEMBL5434856 | US12122771, Compound 8)
Affinity DataKi:  1.74E+4nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent