BDBM50618383 CHEMBL5404063

SMILES Oc1ccc(cc1)C1=C(C2OC1CC2S(=O)(=O)N(CC(F)(F)F)c1ccccc1)c1ccc(cc1)-n1cncn1

InChI Key

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50618383   

TargetEstrogen receptor(Human)
Zhongnan Hospital of Wuhan University

Curated by ChEMBL
LigandPNGBDBM50618383(CHEMBL5404063)
Affinity DataEC50:  4nMAssay Description:Antagonist activity against ERalpha in estradiol stimulated HEK293T cells measuring luciferase activity after 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Zhongnan Hospital of Wuhan University

Curated by ChEMBL
LigandPNGBDBM50618383(CHEMBL5404063)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity against ERbeta in HEK293T cells measuring luciferase activity after 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAromatase(Human)
Zhongnan Hospital of Wuhan University

Curated by ChEMBL
LigandPNGBDBM50618383(CHEMBL5404063)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant aromatase using ARO as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
Zhongnan Hospital of Wuhan University

Curated by ChEMBL
LigandPNGBDBM50618383(CHEMBL5404063)
Affinity DataKi:  75nMAssay Description:Binding affinity to ERalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Zhongnan Hospital of Wuhan University

Curated by ChEMBL
LigandPNGBDBM50618383(CHEMBL5404063)
Affinity DataKi:  2.91E+3nMAssay Description:Binding affinity to ERbeta (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed