BDBM50619564 CHEMBL5408905

SMILES C[C@H]1CN(CCN1c1nc(OC[C@@]23CCCN2CC(=C)C3)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)\C=C\c1cccc2C3CCN(C3)Cc12

InChI Key InChIKey=VALDJEIZODIXIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50619564   

TargetGTPase KRas(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50619564(CHEMBL5408905)
Affinity DataIC50: 410nMAssay Description:Inhibition of Biotinylated KRAS G13D mutant (unknown origin) incubated for 20 mins in presence of BODIPY-GDP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50619564(CHEMBL5408905)
Affinity DataIC50: 550nMAssay Description:Inhibition of Biotinylated KRAS G13D mutant (unknown origin) incubated for 20 mins in presence of BODIPY-GDP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed