BDBM50621274 CHEMBL5402124

SMILES COc1cc(cc(OC(F)F)c1C(=O)NC1CC1)-c1cnc2cc(ccn12)N1CCN(CC1)C(C)=O

InChI Key InChIKey=SHMKAHZOTDZUIN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50621274   

TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621274(CHEMBL5402124)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621274(CHEMBL5402124)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of full length human SIK2 using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50621274(CHEMBL5402124)
Affinity DataIC50: 45nMAssay Description:Inhibition of N-terminal GST-tagged wild type human SIK1 (1 to 783 residues) expressed in baculovirus-infected Sf21 cells using AMARA peptide as subs...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed