BDBM50621559 CHEMBL5426510

SMILES OC(=O)c1ccccc1OCCc1cn(-c2ccc(cc2)-c2c(Cl)cccc2Cl)c2ccc(cc12)-c1ccc(F)cc1

InChI Key InChIKey=ITDFMPUKGDSVPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50621559   

TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of full-length human recombinant METTL3 (369 to 580 residues) expressed in baculovirus expression system infected in Sf9 cells by fluoresc...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of METTL3/METTL14 (unknown origin) by MTase-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of METTL3 in human Huh-7 cells assessed as down regulation of m6A RNA level at 2 uM incubated for 72 hrs by colorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50621559(CHEMBL5426510)
Affinity DataIC50: 4.92E+3nMAssay Description:Inhibition of METTL3/METTL14 in human MOLM-13 cells assessed as reduction in m6A/A ratioMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed