BDBM50622460 CHEMBL5413819

SMILES FC(F)(F)c1ccc(Nc2cc(ccn2)C(=O)Nc2cnccc2-c2ccccc2)nc1

InChI Key InChIKey=JPWPFXUIMVYLLR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50622460   

TargetGlycogen synthase kinase-3 beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50622460(CHEMBL5413819)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50622460(CHEMBL5413819)
Affinity DataIC50: 0.890nMAssay Description:Displacement of FL-KRREILSRRP[ps]ERYR-NH2 from human recombinant N-terminal His6-tagged GSK-3-beta (14 to 306 residues) H355L mutant expressed in bac...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50622460(CHEMBL5413819)
Affinity DataIC50: 49nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50622460(CHEMBL5413819)
Affinity DataIC50: 49nMAssay Description:Inhibition of GSK-3 in human U2OS cells transfected with beta-catenin GFP and 4R1N tau plasmid assessed as inhibition of Tau phosphorylation at Ser39...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed