BDBM50622849 CHEMBL5408173

SMILES C[n+]1ccc(I)cc1

InChI Key InChIKey=CMNPLPHOVMUCLQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50622849   

TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 440nMAssay Description:Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S/C314S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA)-AMC as substrate and 100 nM HDAC8 preincubated for 1 hr followed by substrate addition and me...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S/C275S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S/C352S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S/C131S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S double mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of HDAC8 C102S/C153S/C125S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of HDAC8 C102S/C153S/C287S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of HDAC8 C102S/C153S/C244S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622849(CHEMBL5408173)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of HDAC8 C102S/C153S/C28S triple mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed