BDBM50622893 CHEMBL5439733

SMILES C[n+]1ccc(NC(=O)CC(=O)N2Cc3ccccc3C2)c(c1)C#C

InChI Key InChIKey=ZJLYDUUICUAMPZ-UHFFFAOYSA-O

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50622893   

TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622893(CHEMBL5439733)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) assessed as inhibition constant using Boc-Lys(TFA)-AMC as substrate by fluorescence based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622893(CHEMBL5439733)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622893(CHEMBL5439733)
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Hun-Ren Research Centre for Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50622893(CHEMBL5439733)
Affinity DataIC50: 5.88E+4nMAssay Description:Inhibition of HDAC8 C153S mutant (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 1 hr followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed