BDBM50622909 CHEMBL5431938

SMILES CCNC(=O)c1c(OC)cc(cc1OC(F)F)-n1cnc2cc(ccc12)-c1cnn(CC)c1

InChI Key InChIKey=VNWAWEZKWMFEJY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50622909   

TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of SIK2 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of SIK1 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 172nMAssay Description:Inhibition of Abl1 (unknown origin) using poly (Glu,Tyr) as substrate incubated for 45 to 60 mins in presence of ATP by [33P]-gammaATP based Topcount...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 194nMAssay Description:Inhibition of FMS (unknown origin) using poly (Glu,Tyr) as substrate incubated for 45 to 60 mins in presence of ATP by [33P]-gammaATP based Topcount ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 380nMAssay Description:Inhibition of human LynA using poly (Glu,Tyr) as substrate incubated for 45 to 60 mins in presence of ATP by [33P]-gammaATP based Topcount scintillat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ALK5 (unknown origin) using casein as substrate incubated for 45 to 60 mins in presence of ATP by [33P]-gammaATP based Topcount scintil...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTGF-beta receptor type-2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of TGFbetaR2 (unknown origin) autophosphorylation incubated for 45 to 60 mins in presence of ATP by [33P]-gammaATP based Topcount scintill...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622909(CHEMBL5431938)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of AMPK alpha1/beta2/gamma1 (unknown origin) using SAMStide as substrate incubated for 45 to 60 mins in presence of 5'AMP and ATP by [33P]...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed