BDBM50625744 CHEMBL5401125

SMILES CC[C@H](C)Nc1cc(Nc2ccnc(n2)-c2cnn(c2)S(=O)(=O)C2CC2)ncc1C(=O)N(C)C

InChI Key InChIKey=HZFZXDVTLANIJS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50625744   

TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625744(CHEMBL5401125)
Affinity DataIC50: 300nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625744(CHEMBL5401125)
Affinity DataIC50: 450nMAssay Description:Inhibition of EGFR Del19/T790M/C797S mutant (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50625744(CHEMBL5401125)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of wild-type EGFR (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed