BDBM50627124 CHEMBL5413349

SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O)[C@]1(C[C@H](C)C1)c1nncn1C

InChI Key InChIKey=UKFKDADMCDDXJG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50627124   

LigandPNGBDBM50627124(CHEMBL5413349 | US12187709, Compound 3)
Affinity DataIC50: 2.5nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627124(CHEMBL5413349 | US12187709, Compound 3)
Affinity DataIC50: 3.60nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50627124(CHEMBL5413349 | US12187709, Compound 3)
Affinity DataIC50: 4nMAssay Description:Inhibition of biotin-tagged Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination using His-LCK as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed