BDBM50627125 CHEMBL5413442

SMILES Cn1cnnc1[C@@]1(C[C@H](Cl)C1)c1cccc(c1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O

InChI Key InChIKey=UEPKOBLDGLEGJN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50627125   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataKd:  0.75nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataKd:  1.30nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataIC50: 4nMAssay Description:Inhibition of biotin-tagged Cbl-b (unknown origin) assessed as reduction in LCK ubiquitination using His-LCK as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataIC50: 4.10nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataKd:  4.20nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataIC50: 4.20nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataKd:  6.60nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataIC50: 6.80nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM50627125(CHEMBL5413442 | US12187709, Compound 446)
Affinity DataIC50: 11nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent