BDBM50629514 CHEMBL5402623

SMILES Cc1ccc(c(F)c1)-c1c(C)nc(N2CCC3(Cc4ncccc4[C@H]3N)CC2)c2ccnn12

InChI Key InChIKey=LHBBGNUOZGONQB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50629514   

LigandPNGBDBM50629514(CHEMBL5402623 | US20250282782, Compound 186)
Affinity DataIC50: 2nMAssay Description:Inhibition of SHP2 phosphatase activity was evaluated using human recombinant 6His-Nterm (SEQ ID NO: 1) SHP2 full-length (Thr2-Arg593, R&D system), N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

LigandPNGBDBM50629514(CHEMBL5402623 | US20250282782, Compound 186)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length N-terminal his6-tagged human recombinant SHP2 phosphatase activity using DiFMUP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed