BDBM50632509 CHEMBL5414886

SMILES C[C@H]1C[C@@H](N)CN(C1)c1ncnc2[nH]c(Cl)c(-c3cnn(C)c3)c12

InChI Key InChIKey=GHLFOJOOBSNVFP-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50632509   

LigandPNGBDBM50632509(CHEMBL5414886)
Affinity DataKi:  5.20nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50632509(CHEMBL5414886)
Affinity DataKi:  223nMAssay Description:Inhibition of full length C-terminal his6-tagged human recombinant PKCtheta using -FAMRFARKGSLRQKNV-COOH peptide as substrate preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50632509(CHEMBL5414886)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed