BDBM50632897 CHEMBL5425043

SMILES Cc1n[nH]c2ncc(cc12)-c1nnc2CC[C@@H](c3ccc(Cl)cc3)n12

InChI Key InChIKey=LFAHWMOZPVCJAY-UHFFFAOYSA-N

Data  1 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50632897   

TargetCyclin-C(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to GSK3B (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  82nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  86nMAssay Description:Binding affinity to CLK1 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCasein kinase I isoform gamma-3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  670nMAssay Description:Binding affinity to CSNK1G3 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase LATS2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  730nMAssay Description:Binding affinity to LATS2 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to DYRK1B (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632897(CHEMBL5425043)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to VPS34 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed