BDBM50632968 CHEMBL5409772

SMILES [2H]C([2H])([2H])Oc3cccc(c2cc(F)c(NC(=O)C1=C(C(=O)NO)CCC1)c(F)c2)c3

InChI Key InChIKey=FSUASWNEEUYVRO-FIBGUPNXSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50632968   

LigandPNGBDBM50632968(CHEMBL5409772 | WO2004/056746, Example 4)
Affinity DataIC50: 174nMAssay Description:The in vitro inhibition of hDHODH was measured using an N-terminally truncated recombinant hDHODH enzyme as described in J. Med. Chem. 2006; 49:1239....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2025
Entry Details
US Patent

TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50632968(CHEMBL5409772 | WO2004/056746, Example 4)
Affinity DataEC50:  460nMAssay Description:Agonist activity at human Nurr1-LBD transfected in HEK293T cells co-transfected with pFR-Luc/pRL-SV40 assessed as transfection efficiency by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50632968(CHEMBL5409772 | WO2004/056746, Example 4)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant DHODH by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50632968(CHEMBL5409772 | WO2004/056746, Example 4)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro inhibition of hDHODH was measured using an N-terminally truncated recombinant hDHODH enzyme as described in J. Med. Chem. 2006; 49:1239....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2025
Entry Details
US Patent