BDBM50633493 CHEMBL5440746

SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc2ccc(c(c2F)C(=O)c3c[nH]c4c3cc(cn4)Cl)F

InChI Key InChIKey=GCVULUAJPYRJHT-UHFFFAOYSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50633493   

TargetSerine/threonine-protein kinase B-raf(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM50633493(CHEMBL5440746)
Affinity DataIC50: 48nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM50633493(CHEMBL5440746)
Affinity DataIC50: 56nMAssay Description:Inhibition of wild type B-RAF (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)