BDBM50635714 CHEMBL5558159::US20250268873, Compound 569
SMILES CC(C)NCCOc1ncc(-c2cc3c4c(cnc3cc2F)N(C)C(=O)C42CCC2)cc1NS(C)(=O)=O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50635714
Affinity DataIC50: 0.630nMAssay Description:On day one, a 96-well plate (ThermoFisher, Cat #: 442404) was coated with GST-p53 (1-101) peptide (purified by Pharmaron, BCS department) by diluting...More data for this Ligand-Target Pair
Affinity DataIC50: 0.890nMAssay Description:Inhibition of DNA-PK in human HCT-116 cells measured after 1 hr by Bradford assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
XRAD Therapeutics
US Patent
XRAD Therapeutics
US Patent
Affinity DataIC50: 16nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
XRAD Therapeutics
US Patent
XRAD Therapeutics
US Patent
Affinity DataIC50: 73nMAssay Description:PI3Kα and PI3Kδ Kinase reactions were performed in a 5 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008280 plates were used...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:mTOR Kinase reactions were performed in a 10 μL volume in low-volume 384-well plates. Typically, PerkinElmer model 6008260 plates were used. The comp...More data for this Ligand-Target Pair