BDBM50635997 CHEMBL5555788

SMILES COc1ccc(-c2n[nH]c3ncc(-c4ccc(N5CCN(C)CC5)cc4)cc23)cc1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50635997   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50635997(CHEMBL5555788)
Affinity DataIC50: 12nMAssay Description:Inhibition of HPK1 (unknown origin) preincubated for 10 mins followed by ATP addition measured after 60 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50635997(CHEMBL5555788)
Affinity DataIC50: 15nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50635997(CHEMBL5555788)
Affinity DataIC50: 22nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50635997(CHEMBL5555788)
Affinity DataIC50: 502nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as decrease in SLP-76 phosphorylation at Ser376 incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed