BDBM50636431 CHEMBL5561973

SMILES FC(F)c1c(Br)c(Br)cc2c1nc(N1CCNCC1)n2C1CCOCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50636431   

TargetCyclin-C(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 2.10nMAssay Description:Displacement of tracer 236 from CDK8/cyclin C (unknown origin) preincubated for 15 mins followed by tracer addition and measured after 60 mins by FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK8 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of CDK19 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of CLK4 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-C(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of CDK8/CyclinC (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of CDK8 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of CLK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 14nMAssay Description:Inhibition of HASPIN (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 14nMAssay Description:Inhibition of CLK2 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK19 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK2/cyclinE1 (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 43nMAssay Description:Inhibition of CDK2/cyclinA2 (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 15(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 60nMAssay Description:Inhibition of ERK8 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha'(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 65nMAssay Description:Inhibition of CSNK2A2 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 87nMAssay Description:Inhibition of CDK5/p25NCK (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 124nMAssay Description:Inhibition of PIM2 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 132nMAssay Description:Inhibition of CSNK1A1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 158nMAssay Description:Inhibition of DYRK1A (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 194nMAssay Description:Inhibition of CDK5/p35NCK (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 197nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 (unknown origin) by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 353nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 3(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 503nMAssay Description:Inhibition of HIPK3 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase TAO1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50636431(CHEMBL5561973)
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of TAOK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed