BDBM50637598 CHEMBL5542461

SMILES Nc1ncnc2c1ncn2CCOc1ccc(Br)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50637598   

TargetHistone-lysine N-methyltransferase NSD3(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant NSD3 (1021 to 1322 residues) (unknown origin) expressed in Escherichia coli Rossetta (DE3) assessed as dissociation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant NSD2 (942 to 1240 residues) (unknown origin) expressed in Escherichia coli Rossetta (DE3) using H3K36me1 as substrate incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 840nMAssay Description:Inhibition of recombinant NSD3 (1021 to 1322 residues) (unknown origin) expressed in Escherichia coli Rossetta (DE3) using H3K36me1 as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataKd:  4.87E+3nMAssay Description:Binding affinity to recombinant NSD3 (1021 to 1322 residues) (unknown origin) expressed in Escherichia coli Rossetta (DE3) assessed as dissociation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant G9a (unknown origin) preincubated for 20 mins followed by peptide substrate/SAM addition measured after 3 hrs by MTase Glo ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant SMYD3 (unknown origin) preincubated for 20 mins followed by peptide substrate/SAM addition measured after 3 hrs by MTase Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD2(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant SETD2 (unknown origin) preincubated for 20 mins followed by peptide substrate/SAM addition measured after 3 hrs by MTase Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant PRMT4 (unknown origin) preincubated for 20 mins followed by peptide substrate/SAM addition measured after 3 hrs by MTase Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Jiangsu University of Technology

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant PRMT1 (unknown origin) preincubated for 20 mins followed by peptide substrate/SAM addition measured after 3 hrs by MTase Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed