BDBM50637918 CHEMBL5560246

SMILES Cc1cc(C)cc(Nc2nccc(-c3cc(C(=O)N[C@@H](C)CN4CCC4)n(C)n3)n2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50637918   

TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal His/GST-tagged SYK (356 to 635 residues) expressed in baculovirus infected Sf21 cells using KKKKKEQE-DEPEG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Mus musculus)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 59nMAssay Description:Inhibition of SYK in mouse BaF3-TEL/SYK cells in absence of IL-3 stimulationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 425nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 60 mins in presence of ATP by KinaseGlo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 822nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 60 mins in presence of ATP by KinaseGlo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of LYN (unknown origin) incubated for 60 mins in presence of ATP by KinaseGlo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Mus musculus)
Nerviano Medical Sciences S.r.l.

Curated by ChEMBL
LigandPNGBDBM50637918(CHEMBL5560246)
Affinity DataIC50: 5.39E+3nMAssay Description:Inhibition of SYK in IL-3 stimulated mouse BaF3-TEL/SYK cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed