BDBM50641028 CHEMBL5550018

SMILES N#Cc1ccc(NC(=O)c2cccc(S(=O)(=O)N3CCCc4ccccc43)c2)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50641028   

TargetProtein cereblon/CUL4A/AR(Human)
Zhejiang Normal University

Curated by ChEMBL
LigandPNGBDBM50641028(CHEMBL5550018)
Affinity DataIC50: 130nMAssay Description:Inhibition of DHT induced androgen receptor transcription in human LNCaP cells cotransfected with PSA-luc and renilla plasmid incubated for 24 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon/CUL4A/AR(Human)
Zhejiang Normal University

Curated by ChEMBL
LigandPNGBDBM50641028(CHEMBL5550018)
Affinity DataIC50: 458nMAssay Description:Binding affinity to androgen receptor LBD (unknown origin) incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Zhejiang Normal University

Curated by ChEMBL
LigandPNGBDBM50641028(CHEMBL5550018)
Affinity DataIC50: 830nMAssay Description:Inhibition of glucocorticoid receptor transcription in human PC-3 cells cotransfected with MMTV-luc and renilla plasmid at incubated for 24 hrs by Du...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Zhejiang Normal University

Curated by ChEMBL
LigandPNGBDBM50641028(CHEMBL5550018)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to his tagged glucocorticoid receptor (unknown origin) assessed as dissociation constant by Biolayer interferometry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Zhejiang Normal University

Curated by ChEMBL
LigandPNGBDBM50641028(CHEMBL5550018)
Affinity DataIC50: 1.78E+4nMAssay Description:Antagonist activity at glucocorticoid receptor in human HeLa cells incubated for 24 hrs by luminescence based firefly luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed