BDBM50641289 CHEMBL5572034

SMILES CN1CCN(Cc2ccc(NC(=O)c3cncc(C#Cc4cnc(N)c5ncccc45)c3)cc2C(F)(F)F)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50641289   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 0.950nMAssay Description:Binding affinity to human recombinant RET V804M mutant assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 1nMAssay Description:Binding affinity to human recombinant RET V804L mutant assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity to wild type RET (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 3nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641289(CHEMBL5572034)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length His-tagged human recombinant RET expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed