BDBM50642757 CHEMBL5592177::US20250230147, Compound 154

SMILES Cn1cnnc1[C@@H](F)C1(c2cccc(N3Cc4c(cc(CN5CC6(C5)CC6(F)F)cc4C(F)(F)F)C3=O)c2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50642757   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50642757(CHEMBL5592177 | US20250230147, Compound 154)
Affinity DataIC50: 72nMAssay Description:Inhibition of Cbl-b (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50642757(CHEMBL5592177 | US20250230147, Compound 154)
Affinity DataIC50: 72nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50642757(CHEMBL5592177 | US20250230147, Compound 154)
Affinity DataIC50: 220nMAssay Description:Inhibition of C-Cbl (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-C(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50642757(CHEMBL5592177 | US20250230147, Compound 154)
Affinity DataIC50: 230nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent