BDBM50643127 CHEMBL5590391

SMILES c1cc(-c2cc(C3CCNCC3)n[nH]2)c2cc[nH]c2n1

InChI Key InChIKey=KAVINHSQSZLJGI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50643127   

TargetRho-associated protein kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 34nMAssay Description:Inhibition of ROCK2 (unknown origin) incubated for 40 mins in presence of ATP by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 47nMAssay Description:Inhibition of MNK1 (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 60 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 47nMAssay Description:Inhibition of ROCK1 (unknown origin) incubated for 40 mins in presence of ATP by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 121nMAssay Description:Inhibition of MNK1 (unknown origin) incubated for 60 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 135nMAssay Description:Inhibition of MNK2 (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 60 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643127BDBM50643127(CHEMBL5590391)
Affinity DataIC50: 135nMAssay Description:Inhibition of MNK2 (unknown origin) incubated for 60 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed