BDBM50643185 CHEMBL5572737::US20250243196, Compound F-90

SMILES Cc1cc2c(-c3ccc(NC(=O)[C@H](N)CC(C)(C)C)cc3C)ccnc2[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50643185   

TargetCitron Rho-interacting kinase(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to NanoLuc fused-CITK kinase domain (unknown origin) expressed in HEK293T cells assessed as dissociation constant NanoBRET Target En...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCitron Rho-interacting kinase(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataKd:  9.5nMAssay Description:Binding affinity to NanoLuc fused-CITK (unknown origin) expressed in HEK293T cells assessed as dissociation constant NanoBRET Target Engagement Intra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCitron Rho-interacting kinase(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant CITK kinase domain assessed as phosphorylation of substrate ULight-ARTKQTARKSTGGKAPRICQLAGC measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCitron Rho-interacting kinase(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 12nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent

TargetAP2-associated protein kinase 1(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 212nMAssay Description:Inhibition of human AAK1 incubated for 120 mins by [33P]-gammaATP based Radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBMP-2-inducible protein kinase(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 902nMAssay Description:Inhibition of human BIKE incubated for 120 mins by [33P]-gammaATP based Radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of human full length recombinant MNK2 incubated for 120 mins by [33P]-gammaATP based Radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of human full length recombinant HIPK4 using RRRFRPASPLRGP as substrate incubated for 120 mins by [33P]-gammaATP based Radiometric scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ACK1 (1 to 389) using EFPIYDFLPAKKK as substrate incubated for 40 mins by [33P]-gammaATP based Radiometric scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50643185(CHEMBL5572737 | US20250243196, Compound F-90)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human full length recombinant DARK2 using KKRPQRRYSNVF as substrate incubated for 120 mins by [33P]-gammaATP based Radiometric scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed