BDBM50644193 CHEMBL5571683

SMILES COc1cc(OC)c(Cl)c(-c2ccc3nc(Nc4nc(Cl)ccc4[N+](=O)[O-])ncc3c2)c1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50644193   

TargetFibroblast growth factor receptor 4(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged cytoplasmic domain human FGFR4 (460 to 802 residues) expressed in Escherichia coli BL21 (DE3) using CSox as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST tagged cytoplasmic domain human FGFR4 (460 to 802 residues) expressed in Escherichia coli BL21 (DE3) by phosphosen-csox ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to N-terminal GST tagged cytoplasmic domain human FGFR4 (460 to 802 residues) expressed in Escherichia coli BL21 (DE3) assessed as i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-2(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 18nMAssay Description:Inhibition of human wild type S6K2 using RBER-CHKtide as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataEC50:  52nMAssay Description:Inhibition of full length nanoluc-fused FGFR4 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 490nMAssay Description:Inhibition of human FGFR2 in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataEC50:  684nMAssay Description:Inhibition of full length nanoluc-fused FGFR1 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataEC50:  1.29E+3nMAssay Description:Inhibition of full length nanoluc-fused FGFR2 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataEC50:  1.43E+3nMAssay Description:Inhibition of full length nanoluc-fused FGFR3 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 4.37E+3nMAssay Description:Inhibition of human FGFR1 using poly[Glu:Tyr] (4:1) as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human wild type TTK using RBER-CHKtide as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human wild type FGFR3 using polyEY as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MAPKAPK2 using KKLNRTLSVA as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Eberhard Karls University Tubingen

Curated by ChEMBL
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MAPKAPK3 using KKLNRTLSVA as substrate in presence of ATP by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed