BDBM50644458 CHEMBL5572309::US20260116889, Example 47

SMILES CN1CCCN(C)c2nc(ncc2C(F)(F)F)Nc2cc(ccc2OC2CC2)C1=O

InChI Key InChIKey=YQFQMFIEKMQHLL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50644458   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Whan In Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50644458BDBM50644458(CHEMBL5572309 | US20260116889, Example 47)
Affinity DataIC50: 2.70nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644458BDBM50644458(CHEMBL5572309 | US20260116889, Example 47)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human LRRK2 G2019S mutant using [RLGRDKYKTLRQIRQ] peptide substrate by [Gamma33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644458BDBM50644458(CHEMBL5572309 | US20260116889, Example 47)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of wild type human LRRK2 using [RLGRDKYKTLRQIRQ] peptide substrate by [Gamma33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644458BDBM50644458(CHEMBL5572309 | US20260116889, Example 47)
Affinity DataIC50: 6.30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Korea Advanced Institute of Science and Technology (KAIST)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644458BDBM50644458(CHEMBL5572309 | US20260116889, Example 47)
Affinity DataIC50: 7nMAssay Description:Inhibition of NanoBRET LRRK2 (unknown origin) G2019S mutant expressed in HEK293 cells by NanoBRET TE Intracellular Kinase AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed