BDBM50645311 CHEMBL5568747

SMILES COc1cc(-c2cnc3nc2NCCCNS(=O)(=O)c2cccc(c2)N3)ccc1Br

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50645311   

TargetCyclin-G-associated kinase(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataKd:  14nMAssay Description:Binding affinity to recombinant his tagged GAK (unknown origin) assessed as dissociation constant by surface plasmon resonance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50:  27nMAssay Description:Inhibition of full length GAK (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K10 tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEphrin type-A receptor 4(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50:  57nMAssay Description:Inhibition of full length EPHA4 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K4 tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataKd:  148nMAssay Description:Binding affinity to recombinant his tagged EPHA2 (D596 to G900 residues) (unknown origin) expressed in Escherichia coli rosetta BL21(D3)-R3-pRARE2 co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50:  260nMAssay Description:Inhibition of full length EPHA2 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K4 tr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50:  1.80E+4nMAssay Description:Inhibition of full length FGFR1 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K10 t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50:  3.30E+4nMAssay Description:Inhibition of full length FLT1 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K9 tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50645311(CHEMBL5568747)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length ABL1 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K4 tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed