BDBM50645374 CHEMBL5574295

SMILES Cc1ccc2c(-c3ccc4ncnc(N[C@H](CO)c5ccccc5)c4c3)c[nH]c2n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50645374   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of DYRK1A (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 1nMAssay Description:Inhibition of DYRK1B (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CLK1 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataEC50:  11nMAssay Description:Inhibition of DYRK1A in human HEK293T cells expressing human Tau P301L mutant assessed as downregulation of Tau phosphorylation at Thr212 residue inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 14nMAssay Description:Inhibition of DYRK2 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 17nMAssay Description:Inhibition of DYRK3 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataEC50:  17nMAssay Description:Inhibition of DYRK1A in human SH-SY5Y cells expressing human Tau P301L mutant assessed as downregulation of Tau phosphorylation at Thr212 residue inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 39nMAssay Description:Inhibition of CLK4 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 39nMAssay Description:Inhibition of CLK3 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 401nMAssay Description:Inhibition of DYRK4 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of GSK-3beta (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed