BDBM50645749 CHEMBL5083143

SMILES c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50645749   

TargetActivin receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 6nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  27nMAssay Description:Inhibition of ALK2 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  225nMAssay Description:Inhibition of ALK1 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 425nMAssay Description:Inhibition of human ALK3 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  497nMAssay Description:Inhibition of ALK3 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 501nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 539nMAssay Description:Inhibition of human KHS using myelin basic protein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 751nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  997nMAssay Description:Inhibition of ALK6 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetActivin receptor type-1B(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ALK4 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ALK5 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetActivin receptor type-1B(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of ALK4 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  1.07E+4nMAssay Description:Inhibition of KHS NanoLuc fusion construct (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of DDR1 NanoLuc fusion construct (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataEC50:  2.86E+4nMAssay Description:Inhibition of FLT3 NanoLuc fusion construct (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed