BDBM50645810 CHEMBL5589612

SMILES CO[C@@]1(C)[C@H](O)C(=O)C(C)=C2OC(=O)c3c(C)cc(O)c(C)c3O[C@@H]21

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50645810   

TargetCyclin-dependent protein kinase PHO85(Baker's yeast)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataEC50:  31nMAssay Description:Binding affinity to yeast Pho85 pretreated with yeast lysates for 45 mins followed by incubation with Kinobead-Sepharose affinity matrix slurry for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataEC50:  140nMAssay Description:Inhibition of CDK2/Cyclin E1 NanoLuc fusion vector (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataEC50:  300nMAssay Description:Inhibition of CDK7/Cyclin H/MAT1 NanoLuc fusion vector (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataEC50:  610nMAssay Description:Inhibition of CDK1/Cyclin B1 NanoLuc fusion vector (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataIC50: 640nMAssay Description:Inhibition of CDK2 in human OVCAR-3 cells assessed as reduction in Rb phosphorylation at T821 residue treated for 4 hrs followed by drug wash-out and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataIC50: 950nMAssay Description:Inhibition of CDK2 in human OVCAR-3 cells assessed as reduction in Rb phosphorylation at T821 residue treated for 4 hrs followed by drug wash-out and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2 in human OVCAR-3 cells assessed as reduction in Rb phosphorylation at T821 residue measured after 120 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK2 in human OVCAR-3 cells assessed as reduction in Rb phosphorylation at T821 residue measured after 18 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645810(CHEMBL5589612)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human full length CDK2 (1 to 298 residues)/N-terminal GST-tagged Cyclin E1 (1 to 410 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed