BDBM50645828 CHEMBL5594198

SMILES N=C(N)Nc1ncc(CN2C(=O)c3ccccc3C2C(=O)NCc2ccc(F)cc2)s1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50645828   

TargetProtein arginine N-methyltransferase 5(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataKd:  1nMAssay Description:Binding affinity to apo PRMT5 (1 to 637 residues)(unknown origin) expressed in baculovirus infected Sf21 insect cells assessed as dissociation consta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to apo PRMT5 (1 to 637 residues)(unknown origin) expressed in baculovirus infected Sf21 insect cells using SAM as substrate assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataIC50: 29nMAssay Description:Inhibition of PRMT5 (1 to 637 residues)/MEP504 (2 to 342 residues)(unknown origin) expressed in baculovirus infected Sf21 insect cells using histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataIC50: 99nMAssay Description:Inhibition of PRMT5 (1 to 637 residues)/MEP504 (2 to 342 residues)(unknown origin) expressed in baculovirus infected Sf21 insect cells using histone ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataIC50: 660nMAssay Description:Inhibition of PRMT5 in human HCT-116 cells with MTAP KO assessed as decrease in SMDA level incubated for 48 hrs by immunofluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to apo PRMT5 (1 to 637 residues)(unknown origin) expressed in baculovirus infected Sf21 insect cells assessed as dissociation consta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50645828(CHEMBL5594198)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PRMT5 in human HCT-116 cells expressing wild-type MTAP assessed as decrease in SMDA level incubated for 48 hrs by immunofluorescence an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed