BDBM50645884 CHEMBL5591040

SMILES Cn1ccc([C@H]2C[C@H](N(c3cc(F)c(NC(=O)c4ccnn(-c5ccc(F)cn5)c4=O)cc3F)c3cccn4nccc34)C2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50645884   

TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645884(CHEMBL5591040)
Affinity DataIC50: 4nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET Y1230H mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645884(CHEMBL5591040)
Affinity DataIC50: 5nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET D1228N mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645884(CHEMBL5591040)
Affinity DataIC50: 20nMAssay Description:Inhibition of MET D1228N mutant (unknown origin) transfected in mouse NIH3T3 cells incubated for 1 hr by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645884(CHEMBL5591040)
Affinity DataIC50: 36nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET F1200I mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed