BDBM50648874 CHEMBL5613766

SMILES C=CC(=O)N(c1ccc(O[C@@H]2CC[C@@H](N)C2)cc1)[C@@H](C)c1ccc(C(F)(F)F)c(C#N)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50648874   

TargetBcl-2-related protein A1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648874(CHEMBL5613766)
Affinity DataIC50: 22nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Bfl-1 (1 to 151 residues)(unknown origin) extracted from Escherichia coli BL21-Gold (DE3) using HyLi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648874(CHEMBL5613766)
Affinity DataEC50:  370nMAssay Description:Inhibition of Bfl-1 in human SU-DHL-1 cells assessed as caspase-3/7 activation measured after 6 hrs by UPLC-MRM MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648874(CHEMBL5613766)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Bcl-xl (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648874(CHEMBL5613766)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50648874(CHEMBL5613766)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Mcl-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed