BDBM50649577 CHEMBL5618255

SMILES Cc1nc(-n2ncc3ccc([C@]4(C#N)CC45CC5)cc32)cs1

InChI Key

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50649577   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck & Co.

Curated by ChEMBL

LigandBDBM50649577(CHEMBL5618255)Copy SMILES

Affinity DataIC50: 17nMAssay Description:Inhibition of LRRK2 G2019S mutant in human SH-SY5Y cells assessed as LRRK2 pSer935 phosphorylation incubated for 90 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Merck & Co.

Curated by ChEMBL

LigandBDBM50649577(CHEMBL5618255)Copy SMILES

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human BCRP extracted from HEK293 cells membrane assessed as reduction in [3H]-rosuvastatin uptake preincubated for 5 mins followed by A...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy BDB DOIPubMed
Copy reaction URL