BDBM50649612 CHEMBL5618740

SMILES Cc1cc(C(=O)Nc2cc(NC(=O)c3ccnc4ccccc34)cc(C(F)(F)F)c2)nn1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50649612   

TargetNuclear receptor subfamily 2 group E member 1(Human)
Ludwig-Maximilians-Universitat (LMU) Munchen

Curated by ChEMBL
LigandPNGBDBM50649612(CHEMBL5618740)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLX LBD expressed in HEK293T cells co-transfected with RL/Gal4-VP16 assessed as repression of VP16-induced reporter activit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 2 group E member 1(Human)
Ludwig-Maximilians-Universitat (LMU) Munchen

Curated by ChEMBL
LigandPNGBDBM50649612(CHEMBL5618740)
Affinity DataKd:  160nMAssay Description:Binding affinity to human TLX LBD assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNuclear receptor ROR-alpha(Human)
Ludwig-Maximilians-Universitat (LMU) Munchen

Curated by ChEMBL
LigandPNGBDBM50649612(CHEMBL5618740)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of ROR-alpha (unknown origin) expressed in HEK293T cells co-transfected with RL/Gal4-VP16 incubated for 16 hrs by Dual-Glo Luciferase assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed