BDBM50652922 CHEMBL5678791

SMILES N[C@H]1CC[C@H](S(=O)(=O)N2[C@@H]3CC[C@H]2C[C@@H](NC(=O)c2cc(C4CC4)on2)C3)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50652922   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SMYD3 (unknown origin) N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 32nMAssay Description:Inhibition of SMYD3 in human HEK293T cells co-transfected with MAP3K assessed as inhibition of Lys260 methylation of MAP3K2 by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataEC50:  1.40E+3nMAssay Description:Binding affinity to SMYD3 in human A549 cells for 60 mins by cellular thermal shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SUV39H1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of WHSC1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRDM9 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETD2(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD2 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Epizyme, Inc.

Curated by ChEMBL
LigandPNGBDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed