BDBM50653003 CHEMBL5712065

SMILES CNC(=O)C(Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)c1ccc(OC(C)C)c(Cl)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50653003   

TargetCentromere protein E(Canis lupus familiaris)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to wild-type dog CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to wild-type human CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  73nMAssay Description:Binding affinity to human CENP-E I182L/T183A/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Mus musculus)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  89nMAssay Description:Binding affinity to wild-type mouse CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataIC50: 550nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  4.40E+3nMAssay Description:Competitive-like binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) asses...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed