BDBM50656373 CHEMBL6163085

SMILES Cc1cc(-c2nc3c(F)c(-c4cccc5ccc(F)cc45)c(CCC#N)cc3c3c2cc([C@@H](C)N2CCOCC2=O)n3[C@H]2[C@H]3CN[C@@H]2C3)ccn1

InChI Key InChIKey=VBKZKBQYSHEYNK-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50656373   

TargetGTPase KRas(Human)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656373BDBM50656373(CHEMBL6163085)
Affinity DataKd:  0.940nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Incyte

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656373BDBM50656373(CHEMBL6163085)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of bodipy-loaded KRAS G12D mutant (unknown origin) assessed as GDP-GTP exchange preincubated for 4 hrs followed by GppNHp and SOS1 additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed