BDBM50656764 CHEMBL6151923

SMILES O=c1[nH]ccc2c(-c3cnc4cc(F)ccn34)ccc(Nc3ccc(C4CCOCC4)c(CN4CC[C@H](F)C4)n3)c12

InChI Key InChIKey=FHMXXBCVBMXMSE-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50656764   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal DYKDDDDK recombinant human HPK1 (1 to 346 residues) expressed in Sf21 insect cells preincubated for 10 min followed by fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataEC50:  41nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 1 hr followed by anti-CD3 addition and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 85nMAssay Description:Inhibition of GST-tagged recombinant human MAP4K3 (1 to 380 residues) extracted from Baculovirus infected Sf9 insect cells preincubated for 10 min fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 104nMAssay Description:Inhibition of GST-tagged recombinant human full length MAP4K5 expressed in insect cells preincubated for 10 min followed by fluorescein PKC and ATP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataEC50:  108nMAssay Description:Inhibition of HPK1 in human T cells assessed as increase in IL-2 secretion measured after 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMisshapen-like kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 168nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human MAP4K6 (7 to 139 residues) expressed in Sf21 insect cells preincubated for 10 min followed by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 448nMAssay Description:Inhibition of N-terminal GST tagged recombinant human MAP4K2 (1 to 820 residues) expressed in Sf21 insect cells preincubated for 10 min followed by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656764BDBM50656764(CHEMBL6151923)
Affinity DataIC50: 665nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human MAP4K4 (1 to 328 residues) expressed in Sf21 insect cells preincubated for 10 min followed by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed