BDBM50657715 CHEMBL6151578

SMILES CCn1ccc(-c2cc(-c3cnn(C)c3)cc([C@@H](C)NC(=O)c3ccccc3CCC(=O)NNC(=O)/C=C/C(=O)N3CC(F)(F)C3)c2)n1

InChI Key InChIKey=AOLARWPMASTPCY-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50657715   

TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657715BDBM50657715(CHEMBL6151578)
Affinity DataKi:  0.25nMAssay Description:Inhibition of SARS-CoV-2 PL protease using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657715BDBM50657715(CHEMBL6151578)
Affinity DataKi:  1.40nMAssay Description:Inhibition of SARS-CoV-2 PL protease using ISG15-AMC as substrate preincubated for 30 mins followed by substrate addition measured for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657715BDBM50657715(CHEMBL6151578)
Affinity DataIC50: 100nMAssay Description:Inhibition of SARS-CoV-2 PL protease preincubated for 30 mins followed by substrate addition measured after 3 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed