BDBM50657824 CHEMBL6165372

SMILES CCC[C@@H](C(=O)N1CCc2c(ccs2)C1)NC(=O)c3cccc(c3)Cn4ccnc4

InChI Key InChIKey=DUKKJDZKLSMCLK-UHFFFAOYSA-N

Data  1 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50657824   

TargetWD repeat-containing protein 5(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657824BDBM50657824(CHEMBL6165372)
Affinity DataKd:  69nMAssay Description:Binding affinity to WDR5 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657824BDBM50657824(CHEMBL6165372)
Affinity DataKd:  1.00E+3nMAssay Description:Displacement of FITC-labeled [3H] (1 to 15 ) from WDR5 (unknown origin) assessed as dissociation constant incubated for 30 mins by fluorescence polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657824BDBM50657824(CHEMBL6165372)
Affinity DataIC50: 1.70E+3nMAssay Description:Competitive binding to N-terminally NL-tagged WDR5 (unknown origin) expressed in HEK293T cells using NanoBRET NanoGlo as substrate incubated for 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
University of Toronto

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657824BDBM50657824(CHEMBL6165372)
Affinity DataKd:  4.00E+3nMAssay Description:Displacement of FITC-labeled MILL-WIN from WDR5 (unknown origin) assessed as dissociation constant incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)