BDBM50658842 CHEMBL6169767

SMILES C#Cc1nc(C(=O)N(c2ccc(-c3cnco3)cc2)[C@@H](C(=O)NC(C)(C)C)c2csc3ccccc23)cs1

InChI Key InChIKey=NBLAYHIFDLIFHK-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50658842   

TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Hainan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658842BDBM50658842(CHEMBL6169767)
Affinity DataKd:  20nMAssay Description:Binding affinity to human GPX4 assessed as dissociation constant by MST assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPhospholipid hydroperoxide glutathione peroxidase(Human)
Hainan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658842BDBM50658842(CHEMBL6169767)
Affinity DataEC50:  4.60E+3nMAssay Description:Induction of thermal stabilization of GPX4 in human HT-1080 cells at 57 degree C incubated for 2 hr by CETSA analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed