BDBM50659765 CHEMBL6145107

SMILES Clc1cnc(-n2cnc3ccccc32)nc1OCCc1ccccn1

InChI Key InChIKey=SCTHYJQNPOWQLH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50659765   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659765BDBM50659765(CHEMBL6145107)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659765BDBM50659765(CHEMBL6145107)
Affinity DataIC50: 38nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human MV4-11 cells incubated for 3 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659765BDBM50659765(CHEMBL6145107)
Affinity DataIC50: 54nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human U-937 cells incubated for 3 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659765BDBM50659765(CHEMBL6145107)
Affinity DataIC50: 58nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed