BDBM50659769 CHEMBL6120909

SMILES N[C@H]1C[C@@H](Oc2nc(-n3cnc4ccccc43)ncc2Cl)C1

InChI Key InChIKey=NCKVODCYFKZSJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50659769   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659769BDBM50659769(CHEMBL6120909)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659769BDBM50659769(CHEMBL6120909)
Affinity DataIC50: 26nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human MV4-11 cells incubated for 2 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659769BDBM50659769(CHEMBL6120909)
Affinity DataIC50: 61nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659769BDBM50659769(CHEMBL6120909)
Affinity DataIC50: 406nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human U-937 cells incubated for 2 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed