BDBM50659771 CHEMBL6163769

SMILES Clc1cnc(-n2cnc3ccccc32)nc1O[C@@H]1CCNC1

InChI Key InChIKey=RTLRGXRMFWELCG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50659771   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659771BDBM50659771(CHEMBL6163769)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659771BDBM50659771(CHEMBL6163769)
Affinity DataIC50: 34nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659771BDBM50659771(CHEMBL6163769)
Affinity DataIC50: 45nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human MV4-11 cells incubated for 2 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Northwestern University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659771BDBM50659771(CHEMBL6163769)
Affinity DataIC50: 637nMAssay Description:Inhibition of eIF4E phosphorylation at Ser209 residue in human U-937 cells incubated for 2 hrs by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed